Download Anaerobiosis and stemness : an evolutionary paradigm for by Zoran Ivanovic, Marija Vlaski-Lafarge PDF

By Zoran Ivanovic, Marija Vlaski-Lafarge

Anaerobiosis and Stemness: An evolutionary paradigm offers a context for knowing the numerous complexities and evolutionary positive factors of stem cells and the medical implications of anaerobiosis stem cells. Combining theoretical and experimental wisdom, the authors supply a vast figuring out of ways the absence or low focus of oxygen can play an influential position within the upkeep and self-renewal of stem cells and stem telephone differentiation. This knowing has scientific implications for the fields of regenerative drugs, melanoma biology and transplantation, in addition to mobilephone engineering and mobile remedy. Anaerobiosis and Stemness is a crucial source for stem phone and developmental biologists alike, in addition to oncologists, melanoma biologists, and researchers utilizing stem cells for regeneration.

  • Highlights the molecular and evolutionary positive aspects of stem cells which lead them to so vital to all organic research
  • Explores equipment of isolation, characterization, activation, and upkeep of stem cells
  • Includes versions for medical program in regenerative medication, melanoma treatment, and transplantation

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Extra info for Anaerobiosis and stemness : an evolutionary paradigm for therapeutic applications

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2] Maas DHA, Storey BT, Mastroianni L. Oxygen tension in the oviduct of the rhesus monkey. Fertil Steril 1976;27:1312–7. [3] Fischer B, Bavister BD. Oxygen tension in the oviduct and uterus of rhesus monkeys, hamsters and rabbits. J Reprod Fertil 1993;99:673–9. [4] Garris DR, Mitchell JA. Intrauterine oxygen tension during the estrous cycle in the guinea pig: its relation to uterine blood volume and plasma estrogen and progesterone levels. Biol Reprod 1979;21:149–59. [5] Kaufman DL, Mitchell JA.

It should be stressed that these cultures, stimulated by condition media, were not optimized in terms of survival and proliferation of all cell categories. Optimization of ex vivo cultures of murine bone marrow cells exposed to air oxygen concentration (20–21%) by adding recombinant cytokines allowing an important amplification of committed progenitors, resulted in almost total exhaustion of HSC potential (as measured by MRA and pre-CFC assays) [61,62]. In these conditions, 1% O2 concentration still allowed an important amplification of committed progenitors (although at a lower extent compared to 20% O2) in parallel with the full maintenance of HSCs-MRA [61].

65] Du J, Chen Y, Li Q, Han X, Cheng C, Wang Z, et al. HIF-1α deletion partially rescues defects of hematopoietic stem cell quiescence caused by Cited2 deficiency. Blood 2012;119:2789–98. [66] Zhang J, Niu C, Ye L, Huang H, He X, Tong WG, et al. Identification of the haematopoietic stem cell niche and control of the niche size. Nature 2003;425:836–41. [67] Shima H, Takubo K, Tago N, Iwasaki H, Arai F, Takahashi T, et al. Acquisition of G0 state by CD34-positive cord blood cells after bone marrow transplantation.

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