By Christopher R. Jacobs, Daniel J. Kelly (auth.), Paulo R. Fernandes, Paulo Jorge Bártolo (eds.)
This e-book provides a suite of chapters describing the cutting-edge on computational modelling and fabrication in tissue engineering.
Tissue Engineering is a multidisciplinary box related to scientists from varied fields. the advance of mathematical equipment is sort of appropriate to appreciate cellphone biology and human tissues to boot to version, layout and fabricate optimized and shrewdpermanent scaffolds.
The bankruptcy authors are the celebrated keynote audio system on the first Eccomas thematic convention on Tissue Engineering the place the emphasis used to be on mathematical and computational modeling for scaffold layout and fabrication. this actual sector of tissue engineering, whose aim is to acquire substitutes for tough tissues corresponding to bone and cartilage, is becoming in value.
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Additional resources for Advances on Modeling in Tissue Engineering
Fung YC, Fronek K, Patitucci P (1979) Pseudoelasticity of arteries and the choice of its mathematical expression. Am J Physiol 237:H620-31. 11. Fung YC (1981) The lung–a perspective of biomechanics development. J Biomech Eng 103:91-96. 12. Humphrey JD (2002) Cardiovascular solid mechanics: cells, tissues and organs. SpringerVerlag. New York. 13. Holzapfel GA (2000) Nonlinear solid mechanics: a continuum approach for engineering, John Wiley & Sons, England 14. Ogden RW (1972) Large deformation isotropic elasticity: on the correlation of theroy and experiment for incompressible rubberlike solids.
In this approach, an assumption is made concerning how these local stimuli affect tissue regeneration (see for example, [1-3]). A scaffold design is proposed and tissue response is calculated. This approach allows parametric simulation of how scaffold design affects tissue regeneration. Although this approach is extremely useful for evaluating scaffold design and likely close to physiologic reality, it is not known how uncertainty in boundary condition and heterogeneous tissue constitutive properties will influence the how close the simulation matches real life.
95) by the Ogden model (Table 1). Table 1. Base nonlinear elastic properties fit to a 1-term Ogden model for bioresorbable elastomers POC, PGS, PGD. Model parameters depend on synthesis conditions including curing temperature and time, which alters crosslink density. 5 Nonlinear Elastic Scaffold Design 47 Our group has also been able to fabricate porous scaffolds from POC and PGS, using designed solid free-form fabricated techniques (Figure 7). These designed porous scaffolds had either cylindrical pores of 32% (c32), 44% (c44), or 62% (c62) porosity or a spherical pore with 50% porosity (s50).