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By Gerd Plewig Prof. Dr., Albert M. Kligman M.D., Ph.D. (auth.)

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13-cis retinoic acid (isotre- This leads to a reduction of sebum protinoin) causes a marked decrease in se- duction. Spironolactone needs special bum production and a drastic shrinkage mention as it is an alternative to cyproof the glands to up to 90% of the level terone acetate in those countries where before treatment. The decrease in sebum this drug is not available. It should be production is dose-dependent and starts kept in mind, however, that all these within the first two weeks of treatment.

Usually dense colonies of Propionibacterium acnes are present, not seen in this particular section. One sebaceous acinus is attached to the lower left Right Horizontal cut through a follicular filament. This could be the horizontal counterpart to the vertical section above right. The follicular epithelium shows a stratum granulosum and encases a filament of corneocytes. The chambers are full of Propionibacterium acnes; one tiny brownish hair is below 18 Scanning Electron-Microscopic Overview of a Sebaceous Follicle Rarely can one see the full architectural pattern of a sebaceous follicle.

The volume of a mature cell may be 100-150 times larger than that of the basal cell from which it is derived. Active synthesis of lipids results in great expansion of sebocytes. In contrast to the subcutaneous adipose tissue where the lipids confluate within the adipocyte, mature sebocytes still contain individual lipid vacuoles, sometimes more than 50, separated by fine cytoplasmic strands. The cytoplasm also contains a well-developed Oolgi apparatus and rough endoplasmic reticulum. Sebocytes, like the keratinocytes of the epidermis, can also synthesize sparse tonofilaments.

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